|
KMID : 1098420050130030087
|
|
Korean Journal of Medicinal Crop Science
2005 Volume.13 No. 3 p.87 ~ p.92
|
|
|
Screening of Anticancer and Immune Activities by the Extracts of Fatsia japonica Decne. et Planch
|
|
Kim Dae-Ho
Kim Jung-Hwa
You Jin-Hyun
Kim Cheol-Hee
Kwon Min-Cheol
Lee Hak-Ju
Lee Hyeon-Yong
Hwang Baik
|
|
|
Abstract
|
|
|
|
The study was performed using of ethanol and water extracts of Fatsia japonica Decne. et Planch. in anticancer and immune activities. All extracts of 1.0 g/{ell} concentration were increased in over 60% of the anticancer activites in A549 and MCF7 cells. Root barks inhibited 55%, 74% in A549 and MCF7 cell by adding ethanol extracts of g/{ell} concentration. The cytotoxicity of human lung nomal cell (HEL299) counted up to about 22% for ethanol extracts of root barks in 1 g/{ell} concentration. The activity of human immune T and B cells were increased up to 140{sim}170% by adding ethanol extract of the root barks. Increasing trend of secretion of cytokine (IL-6, TNF-{alpha}) from human B and T cell for 5 days cultivation has been abserved. From the results, the anticancer and immune-stimulatory activities of the roots extract were higher than the extracts of other parts.
|
|
|
KEYWORD
|
|
|
anticancer activites, immune activities, Fatsia japonica, IL-6, TNF-{alpha}
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|